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Comparative Analysis of Best Nasal Sprays for COVID-19 Prevention

By Udi Damari on Jun 05, 2024 0 Comment

Comparative Analysis of Best Nasal Sprays for COVID-19 Prevention

Since the COVID-19 pandemic, many vaccines and treatments have been developed to prevent or reduce the infection. Nasal sprays like Enovid SaNOtize Nitric Oxide Nasal Spray are becoming increasingly popular because they have shown promising results in providing additional protection against the virus.

In this analytical guide, learn more about the top nasal sprays for COVID-19 prevention and how they compare against each other. Let's get started!

How Nasal Sprays Block an Infection

Before we go over the top three options to determine the best nasal spray for COVID-19 prevention, it's crucial to understand how these types of medication work. Typically, there are two ways they can block an infection. 

Nasal Sprays with Barrier-forming Ingredients

These types of nasal sprays work by creating a physical barrier over the healthy cells in the nasal passages. When the COVID-19 virus enters the respiratory system, it attaches to the medicine coating instead of infecting the cells. 

The barrier-forming ingredient, iota-carrageenan (I-C), is an antiviral sulfated polysaccharide that effectively blocks the COVID-19 virus. In a 2021 study, 400 Argentinian healthcare workers received four daily doses of I-C spray or placebo for 21 days. 

According to the results, 5% of the participants who received the placebo contracted the COVID-19 virus, while only 1% of the healthcare workers receiving I-C treatment exhibited signs of the infection. 

Nasal Sprays with Antimicrobial Ingredients

Another common way nasal sprays block an infection is through antimicrobial ingredients. These prevent the COVID-19 virus from replicating, reducing its impact on the human body. 

One of the most studied antimicrobial ingredients is nitric oxide (NO). Initially, researchers and manufacturers experimented with this miscellaneous respiratory agent class of drugs as a treatment for COVID-19. However, research has shown its effectiveness in preventing mild infections. 

A 2021 study examined the clinical efficacy of nitric oxide nasal spray (NONS) for treating COVID-19 infections. It recruited 80 participants and divided them into NONS and placebo groups. 

According to the findings, the people who received the NONS showed a 95% reduction in the SARS-CoV-2 viral load within 24 hours. Also, symptom resolution was much faster than those that received the placebo treatment. 

Nasal Sprays with Other Ingredients

Currently, there are two ways that nasal sprays work and they are as follows: 

 

  1. Blocking the virus by creating a protective barrier around the cells
  2. Reducing the SARS-CoV-2 viral load with the use of antimicrobial ingredients like nitric oxide

While other nasal sprays on the market use xylitol and ethyl lauroyl arginate hydrochloride ingredients, they are yet to undergo human trials. As of now, testing done on cells in a dish shows weaker results.

The Top Three Nasal Sprays for COVID-19 Prevention

Currently, there are different types of nasal sprays on the market, each claiming to prevent COVID-19 and other infections. However, only a few have undergone testing and shown promising results. 

Here are the top three nasal sprays for COVID-19 prevention: 

SaNOtize NONS by Enovid

SaNOtize NONS generates and releases a low dose of NO, which helps eliminate airborne viruses, such as the SARs-CoV-2, from the nasal cavity. It's sold under the brand name Virx in some countries.

What's great about SaNOtize NONS is that it acts instantly and does not allow the vial microbes to incubate and proliferate in the respiratory system. 

pHOXWELL by pHOXBIO

pHOXWELL is virucidal, which is often complemented with PPE and vaccines for the best results. It's designed to prevent respiratory infections and the new strains of coronaviruses, influenzas, and rhinoviruses.

IGM-6268 by IGM Biosciences

IGM-6288 is an anti-SARS-CoV-2 IgG monoclonal antibody currently under development. It offers 100 times greater neutralizing potency when it binds to SARS-CoV-2.

Comparative Analysis of Top Nasal Sprays for COVID-19 Prevention

Here is a comparative analysis chart to help you determine the best nasal spray for COVID prevention: 

SaNOtize NONS pHOXWELL IGM-6268
It uses antimicrobial ingredients like nitric oxide to prevent infections. It uses natural virucides to bind to the viruses and destroy them. It neutralizes viruses, including SARS-CoV-2, using antibodies.
Clinical Trials Yes (Phase 1, 2, and 3) Yes (Phase 1, 2, and 3) In progress
Results According to the Glenmark Phase III clinical trial, the Enovid SaNOtize NONS effectively reduced SARS-CoV-2 log viral load by 94% in the first 24 hours and 99% in 48 hours. A randomized control trial showed that the nasal spray reduced the risk of developing COVID-19 by 62%. IGM-6268 is currently undergoing clinical trials on participants to determine the effectiveness of the nasal spray in preventing mild to moderate cases of COVID.

 

Final Thoughts on the Best Nasal Spray for COVID Prevention

Among the products in the chart above, SaNOtize NONS is the only one currently available. It's safe to use and well tolerated by the users. Additionally, all three phases of the clinical trials didn't reveal any adverse side effects or deaths.

Enovid SaNOtize NONS is the best nasal spray for COVID prevention due to its effectiveness in reducing the viral load and killing the viruses in the nasal cavity. Plus, it's made from natural ingredients and is super easy to use. 

Take the first step towards protecting yourself from viruses and head over to BuyEnov.com to get your hands on the Enovid SaNOtize NONS today!

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